To explore the efficiency and safety of CLAG regimen in R/R ALL
R/R Acute Lymphoblastic Leukemia has poor response to second-line chemotherapy.Here,we want to explore efficiency and safety of CLAG regimen in R/R ALL.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
32
Cladribine combine with cytarabine will be intravenous on days 1-5; G-CSF will be hypodermic injection on day0-5,4 weeks per cycle.
Control arm Patients in the control arm received the investigator's choice of one of the following three regimens: FLAG:Fludarabine(30mg/m2)should be intravenous use on day 1-5, granulocyte colony-stimulating factor will be hypodermic injection using 300 μg per day on days 0-5,cytarabine (1.5 mg/m2) every 12 hours, intravenous infusion on day1-5,4 weeks per cycle. a high-dose cytosine arabinoside-based regimen; a high-dose methotrexate-based regimen
The First Affiliated Hospital of Soochow University
Suzhou, Jiangsu, China
RECRUITINGCR (complete remission rate)
Response to CLAG regimen.
Time frame: the first cycle (4 weeks)
Overall survival(OS)
The time from randomization to death from any cause.
Time frame: From the 1st day to the 365th day after enrollment.
Progression-Free Survival (PFS)
It is defined as the total survival of a patient after CR until the tumor recurrence or death from any cause.
Time frame: From the 1st day to the 365th day after enrollment.
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