Study of Comprehensive ANd Multimodal Marker-based Cohort of Progressive Supranuclear Palsy(PSP)

Seoul National University Hospital130 enrolled

Overview

The purpose of this cohort study is to develop a reliable biomarker in progressive nuclear palsy (PSP).

Progressive supranuclear palsy is a rapidly progressive neurodegenerative disease without a cure. Thus, the development of a biomarker that reflects and monitors disease severity in PSP is critical for early diagnosis and performing a successful clinical trial. Thus, we will prospectively recruit patients with PSP and collect comprehensive clinical, imaging and blood biomarkers at baseline with longitudinal follow-up for 1 year.

Study Type

OBSERVATIONAL

Enrollment

130

Conditions

Progressive Supranuclear Palsy

Eligibility

Sex: ALLMin age: 50 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria for the patient group: * Age 50 to 80 years, male or female * Progressive supranuclear palsy (PSP) patients who are diagnosed as Probable, Possible or suggestive PSP with Movement Disorder society diagnostic criteria for PSP (Hoglinger et al., 2017) Exclusion Criteria for the patient group: * Subjects with clinically significant psychiatric illness * Subjects with cancer or severe medical illness * Lactating, pregnant, or possibly pregnant * Subjects with small vessel disease (\> grade II) in brain MRI or other structural lesions by causes other than PSP * Subjects with severe dementia patients (MMSE \< 19 or MoCA \<13 or General deterioration scale \>= 5) Inclusion Criteria for the healthy control group: * Age 50 to 80 years, male or female * Those who agreed to participate in this study Exclusion Criteria for the healthy control group: * Those with a history of any neurological diseases * Lactating, pregnant, or possibly pregnant * Subjects with clinically significant psychiatric illness * Subjects with cancer or severe medical illness

Locations (2)

Seoul National University Boramae Hospital

Seoul, South Korea

RECRUITING

Seoul National University Hospital

Seoul, South Korea

RECRUITING

Outcomes

Primary Outcomes

Change in the Progressive Supranuclear Palsy Rating Scale (PSP-RS)

A scale for assessment of motor and non-motor symptom severity in PSP patients. The PSPRS comprises 28-items with total score ranges from 0 (normal) to 100.