Pressure Gradient vs. Flow Relationships in Patients With Symptomatic Valvular Aortic Stenosis

Aarhus University Hospital Skejby26 enrolled

Overview

The objective of the present study is to investigate to hemodynamic profile at rest and during peak exercise of patients with suspected severe aortic stenosis and to compare flow- and pressure changes between high gradient patients and low gradient patients.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Aortic Valve Stenosis

Interventions

Simultaneous right and left heart catheterizationPROCEDURE

Pressure recordings across the aortic valve with simultaneous flow measurements by right heart catheterization, during rest and during supine exercise.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with suspected severe AS scheduled for evaluation for aortic valve intervention: * LVEF \> 50 % * AVA \< 1.0 cm2 * Symptomatic - at least equivalent to NYHA functional class II Exclusion Criteria: * Congenital heart disease * Severe coronary artery disease (main stem, proximal LAD or 3 vessel disease) * Moderate or severe aortic valve regurgitation * Moderate or severe mitral valve regurgitation or stenosis * Moderate or severe pulmonary valve regurgitation or stenosis * Moderate or severe tricuspid valve regurgitation or stenosis * Severe pulmonary hypertension (tricuspid valve pressure gradient of 60 mmHg) * Right ventricular dysfunction (TAPSE \< 17 mm) * Restrictive cardiomyopathy or cardiac amyloidosis * Constrictive pericarditis * Inability to perform supine bicycle exercise

Locations (1)

Aarhus University Hospital

Aarhus, Denmark

Outcomes

Primary Outcomes

Pressure and flow relationships across the aortic valve during rest and during supine exercise

Pressure drop across the aortic valve measured invasively. Flow across the valve estimated by right heart catheterization in the absence of aortic valve regurgitation.

Time frame: 2 hours

Data from ClinicalTrials.gov

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