Preoperative biliary drainage predisposes the bile to be contaminated with bacteria of the duodenum. These bacteria colonizing the bile are a potential source for surgical site infections after pancreaticoduodenectomy and many international guidelines recommend the use of cephalosporines as microbial prophylaxis before surgery. The aim of this study was to assess the incidence of bacteria in bile, their resistance profiles and association to surgical site infections in relation to timing of surgery after preoperative biliary drainage in order to better guide antibiotic use.
Study Type
OBSERVATIONAL
Enrollment
376
Preoperative biliary drainage before pancreaticoduodenectomy. Might be needed if the biliary tract in obstructed and the surgery cannot be scheduled in near future.
Helsinki Central Hospital
Helsinki, Finland
Rate of surgical site infections
Time frame: 30 days post operatively
Prevalence of cephalosporin resistance in intraoperative biliary cultures
Time frame: At the time of operation
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