Superficial basal cell carcinoma (sBCC) can be treated non-invasively, but follow-up is necessary because lesions can reoccur. This study aims to evaluate the additional value of optical coherence tomography (OCT) for the detection of recurrent BCC lesions, that may remain unrecognized by clinical and dermoscopic examination (CDE). This study compared the diagnostic accuracy of CDE and CDE combined with OCT for detection of recurrent basal cell carcinoma (BCC) after non-invasive treatment of sBCC.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Enrollment
100
In case of suspicion of recurrence or a voluntary control biopsy; a punch biopsy (3mm) was obtained conform regular care.
Maastricht University Medical Center+
Maastricht, Limbrug, Netherlands
The added value of OCT for the detection of recurrent BCC
The investigators evaluated the difference in sensitivity between CDE and CDE + OCT
Time frame: 1- 56 months post treatment
The number of false-positive OCT test results
The investigators evaluated whether the addition of OCT to CDE led to false-positive test results. (i.e a decrease in specificity)
Time frame: 1- 56 months post treatment
Subtyping recurrent BCC by OCT
The investigators evaluated to what extent OCT assessors are able to correctly predict the BCC subtype of recurrent BCCs. A distinction was made between superficial BCC (sBCC; non-invasive treatment optional) and nodular/aggressive BCC (nBCC/aBCC; excision required). For BCC subtyping, sensitivity was defined as the proportion of patients with an nBCC/aBCC correctly identified by OCT as nBCC/aBCC. Specificity was defined as the proportion of patients with an sBCC correctly identified as sBCC by OCT.
Time frame: 1- 56 months post treatment
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