Factors Associated With Success of NIPPV in ALS Patients

Seoul National University Bundang Hospital51 enrolled

Overview

This is a retrospective cohort study to assess the factor associated with success of non-invasive positive ventilation in ALS patients.

Patients with ALS who were admitted to a tertiary hospital for initially applying non-invasive positive pressure ventilation (NIPPV). The objective of this study was to investigate factors associated with optimal NIPPV initiation and adherence, and to assess the long-term effects of NIPPV adherence in ALS patients.

Study Type

OBSERVATIONAL

Enrollment

Conditions

ALS

Eligibility

Sex: ALLMin age: 19 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients fulfilling the El Escorial World Federation criteria for probable, or definite ALS * Aged ≥ 19 years * Patients who performed blood gas analysis including venous blood gas and arterial blood gas before NIPPV application. Exclusion Criteria: * Patients who had experience in applying the NIPPV or currently using NIPPV * Patients who applied in outpatient settings * Patients who did not perform blood gas analysis before NIPPV application * Patietns who had a history of asthma or COPD, * Patients who didn't have any record of NIPPV application time

Locations (1)

Seoul National University Bundang Hospital

Seongnam-si, South Korea

Outcomes

Primary Outcomes

Success of NIPPV

The success of NIPPV application was defined empirically as use of ≥ 2 hours per day and the failure as use of \< 2 hours for a day or conversion to invasive positive pressure ventilation via tracheostomy or refuse to apply NIPPV during hospitalization.

Time frame: through intervention completion, with an average of 10 days

Secondary Outcomes

Lenght of stay

The length of stay (LOS) was defined as the interval between admission and hospital discharge, and calculated as the number of midnights between admission and discharge from the hospital.

Time frame: through intervention completion, with an average of 10 days

Data from ClinicalTrials.gov

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