The combined measurement of the pulmonary diffusing capacity to carbon monoxide (CO) and nitric oxide (NO) (DLCO/NO) during exercise may be a useful physiological measure of alveolar-capillary reserve in patients with Chronic obstructive pulmonary disease (COPD). The present study investigated the test-retest reliability of DLCO/NO-based metrics.
The combined measurement of the pulmonary diffusing capacity to carbon monoxide (CO) and nitric oxide (NO) (DLCO/NO) has recently been standardised and validated for clinical use. It is thus ideal for assessing acute changes in pulmonary diffusing capacity and its components during various physiological manoeuvres. These changes are thought to involve acute changes in pulmonary perfusion and are notably relevant for patients with chronic obstructive pulmonary disease (COPD), in which they may be related to exertional dyspnoea. The aim of the present study is to investigate the effects of acute exercise on pulmonary diffusing capacity, and to determine the day-to-day repeatability of such assessments.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
15
The measurement will be repeated within one to seven days.
Centre for Physical Activity Research (CFAS)
Copenhagen, Denmark
RECRUITINGRigshospitalet
Copenhagen, Denmark
RECRUITINGRest-to-exercise change in DLNO
The physiological change from rest to exercise in DLNO obtained using the combined DLCO/NO technique with a 5-sec breathhold.
Time frame: Measured at day 1 and day 2
Rest-to-exercise change in DLCOc
The physiological change from rest to exercise in DLCOc obtained using the combined DLCO/NO technique with a 5-sec breathhold.
Time frame: Measured at day 1 and day 2
Rest-to-exercise change in DM
The physiological change from rest to exercise in DM obtained using the combined DLCO/NO technique with a 5-sec breathhold.
Time frame: Measured at day 1 and day 2
Rest-to-exercise change in VC
The physiological change from rest to exercise in VC obtained using the combined DLCO/NO technique with a 5-sec breathhold.
Time frame: Measured at day 1 and day 2
Rest-to-exercise change in VA
The physiological change from rest to exercise in VA obtained using the combined DLCO/NO technique with a 5-sec breathhold.
Time frame: Measured at day 1 and day 2
Smallest real difference (SRD) for Diffusion capacity for DLNO at rest
SRD with 95 % confidence intervals (95% CI) for DLNO at rest
Time frame: Measured at day 1 and day 2
SRD for DLNO during exercise
SRD with 95% CI for DLNO during exercise
Time frame: Measured at day 1 and day 2
SRD for Diffusion capacity for carbon monoxide (DLCOc) at rest
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SRD with 95% CI for DLCOc at rest
Time frame: Measured at day 1 and day 2
SRD for DLCOc during exercise
SRD with 95% CI for DLCOc during exercise
Time frame: Measured at day 1 and day 2
SRD for membrane diffusing capacity (DM) at rest
SRD with 95% CI for DM at rest
Time frame: Measured at day 1 and day 2
SRD for DM during exercise
SRD with 95% CI for DM during exercise
Time frame: Measured at day 1 and day 2
SRD for Pulmonary blood volume (Vc) at rest
SRD with 95% CI for Vc at rest
Time frame: Measured at day 1 and day 2
SRD for Vc during exercise
SRD with 95% CI for Vc during exercise
Time frame: Measured at day 1 and day 2
SRD for alveolar volume (VA) at rest
SRD with 95 % CI for VA at rest
Time frame: Measured at day 1 and day 2
SRD for VA during exercise
SRD with 95 % CI for VA during exercise
Time frame: Measured at day 1 and day 2
Coefficient of Variance (CV) for DLNO at rest
CV with a 95% CI at rest
Time frame: Measured at day 1 and day 2
CV for DLNO during exercise
CV with a 95% CI during exercise
Time frame: Measured at day 1 and day 2
CV for DLCOc at rest
CV with 95% CI for DLCOc at rest
Time frame: Measured at day 1 and day 2
CV for DLCOc during exercise
CV with 95% CI for DLCOc during exercise
Time frame: Measured at day 1 and day 2
CV for DM at rest
CV with 95% CI for DM at rest
Time frame: Measured at day 1 and day 2
CV for DM during exercise
CV with 95% CI for DM during exercise
Time frame: Measured at day 1 and day 2
CV for Vc at rest
CV with 95% CI for DM at rest
Time frame: Measured at day 1 and day 2
CV for Vc during exercise
CV with 95% CI for DM during exercise
Time frame: Measured at day 1 and day 2
CV for VA at rest
CV with 95% CI for VA at rest
Time frame: Measured at day 1 and day 2
CV for VA during exercise
CV with 95% CI for VA during exercise
Time frame: Measured at day 1 and day 2
Intraclass correlation coefficient (ICC) for DLNO at rest
ICC for DLNO with 95% CI at rest
Time frame: Measured at day 1 and day 2
Intraclass correlation coefficient (ICC) for DLNO during exercise
ICC for DLNO with 95% CI during exercise
Time frame: Measured at day 1 and day 2
ICC for DLCOc at rest
ICC for DLCOc with 95% CI at rest
Time frame: Measured at day 1 and day 2
ICC for DLCOc during exercise
ICC for DLCOc with 95% CI during exercise
Time frame: Measured at day 1 and day 2
ICC for DM at rest
ICC for DM with 95% CI at rest
Time frame: Measured at day 1 and day 2
ICC for DM during exercise
ICC for DM with 95% CI during exercise
Time frame: Measured at day 1 and day 2
ICC for VC at rest
ICC for VC with 95% CI at rest
Time frame: Measured at day 1 and day 2
ICC for VC during exercise
ICC for VC with 95% CI during exercise
Time frame: Measured at day 1 and day 2
ICC for VA at rest
ICC for VA with 95% CI at rest
Time frame: Measured at day 1 and day 2
ICC for VA during exercise
ICC for VA with 95% CI during exercise
Time frame: Measured at day 1 and day 2
Diffusion capacity for nitric oxide (DLNO) at rest
DLNO at rest obtained using the combined DLCO/NO technique with a 5-sec breathhold.
Time frame: Measured at day 1 and day 2
Diffusion capacity for nitric oxide (DLNO) during exercise
DLNO during exercise obtained using the combined DLCO/NO technique with a 5-sec breathhold.
Time frame: Measured at day 1 and day 2
Diffusion capacity for carbon monoxide (DLCOc) at rest
DLCOc at rest obtained using the combined DLCO/NO technique with a 5-sec breathhold.
Time frame: Measured at day 1 and day 2
Diffusion capacity for carbon monoxide (DLCOc) during exercise
DLCOc during exercise obtained using the combined DLCO/NO technique with a 5-sec breathhold.
Time frame: Measured at day 1 and day 2
Membrane diffusing capacity (DM) at rest
DM at rest obtained using the combined DLCO/NO technique with a 5-sec breathhold.
Time frame: Measured at day 1 and day 2
Membrane diffusing capacity (DM) during exercise
DM during exercise obtained using the combined DLCO/NO technique with a 5-sec breathhold.
Time frame: Measured at day 1 and day 2
Pulmonary blood volume (Vc) at rest
VC at rest obtained using the combined DLCO/NO technique with a 5-sec breathhold.
Time frame: Measured at day 1 and day 2
Pulmonary blood volume (Vc) during exercise
VC during exercise obtained using the combined DLCO/NO technique with a 5-sec breathhold.
Time frame: Measured at day 1 and day 2
Breath hold time at rest
Breath hold time at rest obtained using the combined DLCO/NO technique with a 5-sec breathhold.
Time frame: Measured at day 1 and day 2
Breath hold time during exercise
Breath hold time during exercise obtained using the combined DLCO/NO technique with a 5-sec breathhold.
Time frame: Measured at day 1 and day 2
Alveolar volume (VA) at rest
VA at rest obtained using the combined DLCO/NO technique with a 5-sec breathhold.
Time frame: Measured at day 1 and day 2
Alveolar volume (VA) during exercise
VA during exercise obtained using the combined DLCO/NO technique with a 5-sec breathhold.
Time frame: Measured at day 1 and day 2
Bland Altman Plot - DLNO
Bland Altman plot for repeated measures for DLNO
Time frame: Measured at day 1 and day 2
Bland Altman Plot - DLCOc
Bland Altman plot for repeated measures for DLCOc
Time frame: Measured at day 1 and day 2
Bland Altman Plot - DM
Bland Altman plot for repeated measures for DM
Time frame: Measured at day 1 and day 2
Bland Altman Plot - VC
Bland Altman plot for repeated measures for VC
Time frame: Measured at day 1 and day 2
Bland Altman Plot - VA
Bland Altman plot for repeated measures for VA
Time frame: Measured at day 1 and day 2