The goal of this clinical trial is to compare resuscitation strategies in patients with cirrhosis and gastrointestinal bleeding. The main question it aims to answer is whether thromboelastography guided resuscitation decreased the amount of fresh frozen plasma patients receive. Patients will receive blood products guided by thromboelastography in the intervention group. Researchers will compare the patients who undergo thromboelastography guided resuscitation to those who receive usual care to see which strategy leads to the use of less blood products, specifically less fresh frozen plasma.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Thromboelastography is a viscoelastic test that measures the dynamics of blood clotting on whole blood samples.
Volume of fresh frozen plasma transfused
The total volume of fresh frozen plasma transfused
Time frame: From time of randomization to hospital discharge, up to 3 months
Patients requiring fresh frozen plasma transfusion
Percentage of patients requiring a fresh frozen plasma transfusion
Time frame: From time of randomization to hospital discharge, up to 3 months
Volume of platelets and cryoprecipitate transfused
The total combined volume of platelets and cryoprecipitate transfused
Time frame: From time of randomization to hospital discharge, up to 3 months
Control of bleeding at 5 days
Percentage of patients who have bleeding controlled at 5 days
Time frame: Measured at 5 days from the time of octreotide order placement
Rebleeding at 42 days
Percentage of patients who experienced in-hospital rebleeding within 42 days
Time frame: The earlier of 42 days from the time of octreotide placement or hospital discharge
Mortality rate during index hospitalization
Percentage of patients who died during the index hospitalization
Time frame: From time of randomization to hospital discharge, up to 3 months
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