Clinical & Biochemical Effect of Atorvastatin in Nano Particles Gel in Periodontitis Treatment

Misr University for Science and Technology24 enrolled

Overview

Periodontitis is a destructive chronic inflammatory disease characterized by periodontium damage and pocket formation between the tooth and the gingival margin resulting in ultimate tooth loss. Various topical anti-inflammatory drugs were used to treat inflammation in periodontitis. Introducing atorvastatin as a novel remedy for periodontitis treatment necessitates developing a syringeable modified delivery system capable of targeting inflammation within the periodontal pockets.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Periodontitis

Interventions

Atorvastatin CalciumDRUG

Atorvastatin loaded into nano particles in-situ gel adjunctive to scaling and debridement

Atorvastatin CalciumDRUG

Atorvastatin loaded into in-situ gel adjunctive to scaling and debridement

Scaling and debridement onlyOTHER

Scaling and debridement only

Eligibility

Sex: ALLMin age: 25 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Systemically healthy patients * Patients with moderate periodontitis Exclusion Criteria: * Pregnant women * Lactating women * Patients with chronic diseases

Locations (1)

Misr University for Science and Technology (MUST)

Giza, Egypt

Outcomes

Primary Outcomes

Probing depth

Time frame: 6 weeks

Bleeding index

Time frame: 6 weeks

Plaque index

Time frame: 6 weeks

Secondary Outcomes

Assessment of transforming growth factor in gingival crevicular fluid

Time frame: 6 weeks

Data from ClinicalTrials.gov

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