Kinetics of cEVs Over the 24-hour Dosing Interval After Low-dose Aspirin Administration

Inclusion Criteria: * patients on low-dose aspirin treatment for cardiovascular prevention for at least 1 month * arterial hypertension if well controlled with stable drug therapy * hypercholesterolemia if well controlled with stable drug therapy Exclusion Criteria: * cigarette smoking insufficiency * clinically significant hepatic insufficiency * clinically significant renal insufficiency * clinically significant cardiac insufficiency * clinically significant pulmonary insufficiency * history of malignant neoplasms (diagnosed and treated within the past 5 years) * pregnancy or lactation * history of malabsorption * regular (daily) alcohol consumption * regular (i.e., more than 3 days per week) non steroidal anti-inflammatory drug intake * type 1 diabetes excluded by islet autoantibodies evaluation (anti-glutamic acid decarboxylase, islet cell cytoplasmic, and IA-2 antibodies), family history of type 1 diabetes, age lower than 40 years, lean phenotype, early requirement for insulin therapy