The Efficacy of PRP Combined With Exercise to Treat Knee Osteoarthritisq

Hebei Medical University Third Hospital120 enrolled

Overview

Objective. In this study, the investigators aimed to investigate the efficacy of combined a single platelet-rich plasma (PRP) and physical exercise (leg swing and quadriceps strengthening exercise) versus PRP and hyaluronic acid (HA) combination therapy. Methods. One hundred and six patients with grade Ⅱ-Ⅲ Knee osteoarthritis (KOA) according to the Kellgren-Lawrence classification were randomly divided into intra-articular injection of PRP combined with leg swing and quadriceps strengthening exercise (group A) and intra-articular combination injections of PRP and HA (group B). Patients in group A received twice intra-articular injection of PRP (2 ml, 2 weeks apart) and regular leg swing and quadriceps strengthening exercise for 3 months. Patients in group B received twice intra-articular combination injections of PRP (2 ml) and HA (2 ml) every 2 weeks. The primary outcome measures were Visual Analogue Scale (VAS) and Western Ontario and McMaster Universities (WOMAC) score. The second outcomes included single leg stance test (SLS) and functional activity by 2 minutes walking test (2MWT) and time up and go test (TUGT). All outcomes were evaluated at baseline and after 1,3,6, and 12 months.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

120

Conditions

Platelet-rich Plasma Physical Exercise

Eligibility

Sex: ALLMin age: 40 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients aged ≥ 45 years old; * KOA was diagnosed according to the American College of Rheumatology Classification Criteria; * patients with the Kellgren-Lawrence grade (K-L grade) for KOA of Ⅰ-Ⅲ; * a history of symptoms more than three month, and patients with independent mobility. Exclusion Criteria: * lower limb axial deviation large than 5° (valgus and varus knee); * patients with diabetes mellitus, sever cardiovascular disease, immunosuppressive status, mental illness or other diseases than might affect the results; * injections or other invasive treatments into the lower extremities were used in the past three months; * patients willing to follow the doctor's recommendation for exercise training; * patients with previous knee fracture or malignancy; * patients with a previous history of hip or knee joint surgery; * patients participating in hip or knee muscle strengthening in the past 3 months; * patients did not complete the intervention strategies or regular follow-up.

Outcomes

Primary Outcomes

Visual Analogue Scale (VAS)

Degree of knee pain during treatment

Time frame: 12 months

Western Ontario and McMaster Universities (WOMAC) score

Severity of knee osteoarthritis

Time frame: 12 months

Secondary Outcomes

single leg stance test (SLS)

Assess the patient's balance

Time frame: 12 months

2 minutes walking test (2MWT)

Assess the patient's functional activity

Time frame: 12 months

time up and go test (TUGT)

Time frame: 12 months

The Efficacy of PRP Combined With Exercise to Treat Knee Osteoarthritisq

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes