Long-term conventional treatment of chronic hypoparathyroidism does not fully restore calcium homeostasis leading to increased morbidity, emergency events and reduced subjective health status. To further investigate general morbidity, hypocalcemic events, subjective and daily life performance in patients with chronic hypoparathyroidism a standardized interview as well as blood sampling and examinations such as echocardiography and renal ultrasound are performed.
Design: In a longitudinal prospective trial the comorbidities, mortality, hypocalcemic and hypercalcemic events and quality of life in patients with chronic hypoparathyroidism will be evaluated by a standardized interview, blood sampling and further examinations such as echocardiography and renal ultrasound. Patients: Patients will be recruited out of the patient population of the University Hospital Wuerzburg. Statistical Analysis: Documentation and analysis will be performed at the Department of Medicine I, Endocrine and Diabetes Unit, University of Würzburg, Germany. Data will be documented after pseudonymisation in a data base. For further analysis data will be compared to sex- and age-matched controls.
Study Type
OBSERVATIONAL
Enrollment
300
Dept. of Endocrinology and Diabetology, Dept. of Medicine I, University Hospital Wuerzburg
Würzburg, Bavaria, Germany
RECRUITINGComorbidites
Comorbidities such as renal diseases, cardiovascular disease, psychiatric diseases under treatment
Time frame: 15 years
Subjective health status
Assessment of the subjective health status by standardized quality of life (QoL) questionnaires (e.g. short form-36, Patient Health Questionnaire 28)
Time frame: 15 years
Hypocalcemic and hypercalcemic events
documentation of frequency of hypocalcemia under standard treatment
Time frame: 15 years
Mortality
Time frame: 15 years
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