To know the clinical and inflammatory characteristics of patients with asthma and associated cardiovascular disease.
Recent studies have shown that asthma could be a risk factor for cardiovascular disease, especially in the female and late-onset subgroups. The two entities share several risk factors, such as chronic inflammation and bronchial remodeling. Eosinophilia, characteristic of asthma, has also been described as a predictor of cardiovascular mortality. The aim of this study is to determine the clinical and inflammatory characteristics of patients with asthma and associated cardiovascular disease, as well as their relationship with eosinophil subtypes, biomarkers of chronic inflammation and bronchial remodeling.
Study Type
OBSERVATIONAL
Enrollment
40
To know the clinical and inflammatory characteristics of patients with asthma and associated cardiovascular disease, as well as their relationship with eosinophil subtypes, biomarkers of chronic inflammation and bronchial remodeling.
Clinical characteristics of patients with asthma
Spirometry with bronchodilator testing
Time frame: 1 year
Associated cardiovascular disease type
Cardiac infarction, stroke or peripheral artery disease
Time frame: 1 year
Eosinophil subtypes
Eosinophil subtypes of patients with asthma and cardiovascular disease
Time frame: 1 year
Biomarkers of chronic inflammation
Transforming growth factor-β, interleukin-5, interleukin-13, interleukin-25 and interleukin-3
Time frame: 1 year
Bronchial remodeling
Bronchial remodeling of patients with asthma and cardiovascular disease measured by analysis of images obtained by thoracic CT scanning
Time frame: 1 year
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