Choroidal Blood Flow in Acute and Chronic Central Serous Chorioretinopathy

Helse Stavanger HF50 enrolled

Overview

Patients with central serous chorioretinopathy (CSC) will be monitored with laser speckle flow graphy (LSFG), swept source optical coherence tomography (SS-OCT) and SS-OCT angiography (SS-OCTA). The aim is to unveil the flow and pulse wave characteristics of the choroidal circulation in acute CSC and chronic CSC.

Acute CSC - The proposed study tests the hypothesis that choroidal blood flow characteristics are related to the eventual resolution of subretinal fluid. Such relation can shed light on pathophysiological disease mechanisms and constitute a biomarker for disease activity. Chronic CSC - The proposed study tests the hypothesis that choroidal blood flow characteristics will change in response to standard treatment with PDT. The research of such changes will increase the understanding of the treatment response. This knowledge will help in the effort to understand the why some patients are non-responsive to the treatment.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Central Serous Chorioretinopathy

Interventions

VerteporfinDRUG

Chronic CSC are receiving one treatment before the observation period.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria:- * Able to sign informed consent * Possible to obtain fundus imaging * Acute CSC ˂4 months of duration in one eye, defined as: 1. Subfoveal presence of SRF on OCT 2. Present attack is 1st -3rd attack of CSC b) Patient history and examination consistent with acute CSC c) Characteristic appearance of acute CSC on fundus autofluorescence (FAF) and OCT * Chronic CSC ≥4 months of duration in one eye, defined as: 1. Subfoveal presence of SRF on OCT 2. Subjective visual loss/symptoms 3. Characteristic appearance of chronic CSC on FAF, fluorescein angiography (FA), and indocyanin angiography (ICGA) and OCT 4. Patient history and examination consistent with chronic CSC Exclusion Criteria: * History of retinal disease other than CSC (e.g. retinal detachment) * Contraindications for FA, ICGA or PDT (only for chronic CSC)

Locations (1)

Stavanger University Hospital, Department of Ophthalmology

Stavanger, Norway

RECRUITING

Outcomes

Primary Outcomes

Change in mean blur rate

Relative changes in choroidal blood flow

Time frame: 6 months

Change in pulse wave form analysis

Changes in the shapes of pulse curves

Time frame: 6 months

Secondary Outcomes

Change in choroidal density

Changes in the tissue density

Time frame: 6 months

Change in choroidal thickness

Changes in the morphology of the choroid

Time frame: 6 months

Central Contacts

Vegard Forsaa, MD PhD

CONTACT

+4748152212 forsaa@gmail.com

Data from ClinicalTrials.gov

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