This study will examine whether adding an amnion-chorion membrane on top of the traditionally used collagen plug will lead to more bone formation compared to the collagen plug only.
Bone grafts and membranes are commonly placed to increase the amount of bone right after tooth extraction and before placing a dental implant. The primary objective of this study is to study the effect of a human amnion-chorion membrane (ACM) in an exposed-barrier ridge preservation technique to a control group without utilizing a ACM. 30 patients requiring a front tooth extraction will be recruited and randomized to receive bone grafting with or without an ACM.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
30
After tooth extraction, the socket will be filled with a collagen plug and covered with an amnion-chorion membrane.
University of Michigan School of Dentistry
Ann Arbor, Michigan, United States
Clinical alveolar ridge dimension changes
Clinically measured alveolar ridge dimension changes in mm using calibers
Time frame: 4 months
Digital alveolar ridge dimension changes
Digitally measured alveolar ridge dimension changes in mm2 using CBCT
Time frame: 4 months
Histological bone density.
Histomorphometry.
Time frame: 4 months
Presence of bone turnover proteins.
Immunohistochemistry.
Time frame: 4 months
Implant survival-Clinical
Clinically assessed by torque test using a torque wrench, measured in N/cm.
Time frame: 6 months
Implant survival-Radiographic
Radiographically assessed through any signs of radiolucency around the implant.
Time frame: 6 months
Esthetic restorative outcomes.
Clinical changes in hard tissue based on the PES score
Time frame: 6 months
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