10-13 patients will be enrolled to receive split face treatment: the control side will be treated with metronidazole cream, the intervention side will be treated with a cold atmospheric plasma device
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
5
Cold atmospheric plasma will be generated on the skin surface using an electric device
The Skin Center Dermatology Group
New City, New York, United States
Efficacy - Investigator global assessment
Rosacea improvement will be evaluated based on clinical photos (worsened, unchanged, mild improvement, substantial improvement, cleared)
Time frame: 6 weeks
RosaQoL change
Rosacea Quality of Life tool: 5-point scale Ranging from 1 (no impact) to 5 (worst impact)
Time frame: 6 weeks
Demodex count change
Change in demodex folliculorum mite density, measured by Reflectance Confocal Microscopy )number of follicles with mite, total number of mites in measured area, number of mites per follicle)
Time frame: 6 weeks
Efficacy - National Rosace Society Expert Committee grading system
Complex scoring system as described by Wilkin et al, J Am Acad Dermatol 2004;50:907-12
Time frame: 6 weeks
Tolerability - Incidence of Treatment-Emergent Adverse Events as assessed by patient review
patient reported adverse effects collected using questionnaires
Time frame: 6 weeks
Tolerability - pain as assessed by NRS scale
Pain assessment using a 0-10 scale, with zero meaning "no pain" and 10 meaning "the worst pain imaginable"
Time frame: 6 weeks
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