Association Between Multiple Coagulation-related Factors and Lymph Node Metastasis in Patients With Gastric Cancer: A Retrospective Cohort Study

Shandong Provincial Hospital516 enrolled

Overview

We initially selected a total of 1128 patients with primary gastric cancer who presented at Shandong Provincial Hospital between January 2018 and October 2022, and retrospectively collected their clinical and pathological data. And retrospectively analyzed preoperative baseline characteristics, preoperative laboratory tests, and postoperative pathological results for these patients

Study Type

OBSERVATIONAL

Enrollment

516

Conditions

Gastric Cancer Stage Lymph Node Metastasis

Interventions

coagulation-related factorsDIAGNOSTIC_TEST

We retrospectively evaluated the relationship between lymph node metastasis and coagulation-related factors in 516 patients with T4a stage gastric cancer.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: 1. patients with primary gastric malignant tumors, 2. patients who underwent radical resection of gastric cancer, 3. patients with a postoperative pathology of adenocarcinoma or signet ring cell carcinoma according to the WTO pathological classification, Exclusion Criteria: 1. patients who have distant metastases, such as liver or lung metastases, were found on preoperative ultrasound and computed tomography (CT) examinations, 2. patients who have received preoperative neoadjuvant chemotherapy, 3. patients who take anticoagulant drugs (such as aspirin) prior to surgery, 4. patients who had any previous coagulation disorder.

Locations (1)

Shandong Provincial Hospital

Jinan, Shandong, China

RECRUITING

Outcomes

Primary Outcomes

Preoperative coagulation-related factors (MA values) of patients

MA values(mm). Measure the data of preoperative MA values in 516 gastric cancer patients to see wether this indicator correlated with tumor stage in patients with gastric cancer.

Time frame: Three years

Preoperative coagulation-related factors (platelet counts) of patients

Platelet counts（x10\^9/L). Measure the data of preoperative platelet counts in 516 gastric cancer patients to see wether this indicator correlated with tumor stage in patients with gastric cancer.

Time frame: Three years

Preoperative coagulation-related factors (fibrinogen levels) of patients

Fibrinogen levels (g/L). Measure the data of preoperative fibrinogen levels in 516 gastric cancer patients to see wether this indicator correlated with tumor stage in patients with gastric cancer.

Time frame: Three years

Preoperative coagulation-related factors (D-dimer) of patients

D-dimer (mg/L). Measure the data of preoperative D-dimer in 516 gastric cancer patients to see wether this indicator correlated with tumor stage in patients with gastric cancer.

Time frame: Three years

Postoperative pathological results of tumor T stage.

Recording the postoperative pathological tumor T stage in 516 patients with gastric cancer.

Time frame: Three years

Postoperative pathological results of tumor N stage.

Recording the postoperative pathological tumor N stage in 516 patients with gastric cancer.

Time frame: Three years.

Central Contacts

Feng Tian, Doctor

CONTACT

18866102886 tianfeng@sdu.edu.cn

Changqing Jing, Doctor

CONTACT

15168888987 jingchangqing@sdfmu.edu.cn

Data from ClinicalTrials.gov

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