The Nectin-4 protein belongs to the cell adhesion factors family and has a tissue-specific expression spectrum in normal human tissues. However, Nectin-4 is overexpressed in various malignancies, especially those of epithelial origins, such as uroepithelial carcinoma, making Nectin-4 a highly specific and significant imaging target for malignancies. \[68Ga\]N188, a novel molecular probe of PET imaging agent that targets Nectin-4, can be used in the diagnosis and research of a wide variety of Nectin-4 high-expression malignancies, including bladder cancer.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
203
68Ga-N188 is injected intravenously with a dose of 0.06-0.08 mCi/kg.
Peking University First Hospital
Beijing, Beijing Municipality, China
RECRUITINGThe diagnostic efficacy of 68Ga-N188 PET/CT in the evaluation of malignant tumors
Compare the standardized Uptake Value (SUV) of lesions on 68Ga-N188 and 18F-FDG PET/CT
Time frame: 1 year
The diagnostic efficacy of 68Ga-N188 PET/CT in the evaluation of malignant tumors
Compare the number of lesions detected by 68Ga-N188 and 18F-FDG PET/CT, based on the pathology or clinical follow-up as gold standard.
Time frame: 1 year
The dosimetry of 68Ga-N188
Research on the dose distribution of 68Ga-N188 in healthy volunteers and cancer patients by 1-hour dynamic PET/CT acquisition and analyze by the dosimetry software
Time frame: 1 year
Quantitative evaluation of 68Ga-N188
Evaluation of quantitative parameters of 68Ga-N188, such as time-activity curve.
Time frame: 1 year
Correlation with pathological expression
Analyze Nectin-4 expression at the imaging level in combination with Nectin-4 expression in pathological specimens
Time frame: 1 year
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