It has been proved that lithium carbonate can prolong slow wave sleep with few or no side-effects. The aim of the present study is to evaluate postoperative sleep quality of patients undergoing heart valve surgery with cardiopulmonary bypass taken 250mg lithium carbonate after surgery.
This study is a prospective, randomized, controlled (randomized, parallel group, concealed allocation), double-blinded trial. All patients undergoing heart valve surgery with cardiopulmonary bypass will be randomized 1:1 to the treatment intervention with lithium carbonate 250mg (Baoqing, Hunan, China) or calcium carbonate 500mg (Reneed, Beijing, China) after surgery. The objective of the trial is to evaluate the lithium carbonate 250mg on the postoperative night sleep quality. Duration of sleep was collected with polysomnography on second postoperative night. (from 20:00pm to 06:00. Mini-Mental State Examination (MMSE) score was performed on the seventh postoperative day
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
62
Patients undergoing heart valve surgery withcardiopulmonary bypass will take 250mg lithium carbonate
Patients undergoing heart valve surgery withcardiopulmonary bypass will take 500mg calcium carbonate
the First Hospital of China Medical University
Shenyang, Liaoning, China
RECRUITINGsleep quality
Duration of sleep was collected with polysomnography on second postoperative night. (from 20:00pm to 06:00am)
Time frame: on the second postoperative night from 20:00 to 6:00
serum metabolites
This study will characterize the serum metabolites of patients before and after heart valve surgery
Time frame: from baseline to postoperative 72 hours
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