Abstract: Alopecia areata is believed to be an autoimmune disease resulting from a breach in the immune privilege of the hair follicles causing non scarring hair loss. Methods: our study included 40 patients from may 2019 to july 2022 diagnosed clinically, dermatoscopically and pathologically as alopecia areata Data were enrolled from department of dermatology and venereology, Al-Hussein hospital.
For each patient the following will be done : 1. History taking including ( age, sex, disease duration, family history, history of drug intake, smoking and history of any associated disease ). 2. All patients will give a written, informed consent for induction. 3. Basic photographs will be taken to assess site, size (by cm), number, Extent of the patch using D5300 camera with lens (18-55). 4. Patients will be subjected to 3 session of trichloroacetic acid (TCA) 35% one month apart. 5. serial photographs and dermoscopic examination every month will be done and patient will be score. 6. Efficacy will be assessed using prognostic scoring system for density, pigmentation, and texture of growing hair. 7. histopathological examination will be done before the first session and one month after third session.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
40
5\. Patients will be subjected to 3 session of trichloroacetic acid 35% one month apart.
Al-Azhar university, faculty of medicine
Cairo, Egypt
Al-Azhar university
Cairo, Egypt
Mac Donald Hull and Norris grading system
regrowth of vellus hair, regrowth of sparse pigmented terminal hair, regrowth of terminal hair with patches of alopecia and regrowth of terminal hair on scalp.
Time frame: 4 weeks after the end of treatment
Scoring of texture of regrown hair
Fine vellus hair, Intermediate hair,Normal coarse hair
Time frame: after each session and 4 weeks after the end of treatment
Scoring of pigmentation of regrown hair
Partially pigmented, Moderately pigmented, Normally pigmented
Time frame: after each session and 4 weeks after the end of treatment
Scoring for density of hair regrowth
No hair growth, 1%-25% growth, 26%-50% growth, 51%-75% growth and 76%-100% growth
Time frame: after each session and 4 weeks after the end of treatment
Scoring of overall response at the end of the study
No response, Minimal response, Moderate response, Good response and Excellent response
Time frame: after each session and 4 weeks after the end of treatment
histopathological changes
appearance of lymphocytes around hair follicle, appearance of new blood vessels and size of thickness of hair follicles
Time frame: after each session and 4 weeks after the end of treatment
trichoscopic parameters
determine exclamation mark hairs, black dots, yellow dots and broken hairs
Time frame: after each session and 4 weeks after the end of treatment
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