Social Information Processing in Children: an ocUlo-pupillometric Tool for Standard Evaluation

University Hospital, Tours460 enrolled

Overview

The goal of this observational study is to identify behavioral and physiological markers of social alterations in Autism Spectrum Disorders compared to Typically Developping peers. This single-centre study plan to use eye tracking to evaluate social disorders in Autism Spectrum Disorders (ASD). The investigators will estimate oculometric and pupillometric indices as potential ASD biomarkers. The study will last 4 years and will be organized in two phases.

In a first phase (expected to last 12-16 months), after an experimental validation in typical adults, relevant oculometric and pupillometric indices will be identified in a typical population of children and in a clinically diagnosed population of ASD children. In a second phase of the protocol (expected to last 32-36 months), biomarkers identified in the first phase will be tested on a larger population including other neurodevelopmental disorders.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

460

Conditions

Autism Spectrum Disorder

Interventions

eye-trackerOTHER

Eye-tracker recordings of eye movements, gaze direction and pupillary reactivity

Eligibility

Sex: ALLMin age: 1 DayMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Phase 1 All groups have these 2 criteria in common: Free, informed and signed consent of both parents Enrolment in the social security system The other criteria per group are as follows: Group of adult subjects without ASD : Age between 18 and 50 years Group of children without ASD * Age between 2 and 12 years * Group of children with ASD Age between 2 and 12 years Conformity with the diagnostic criteria of ASD according to DSM-V, ICD-10 or ICD-11 Phase 2 * Group of children without TND : Age between 0 and 12 years * Group of children with TND, or whose diagnosis is in progress (via PCO referral) : Age between 0 and 12 years Conformity to the diagnostic criteria of TND Exclusion Criteria: Phase 1: All groups have the 2 common exclusion criteria Known uncorrected visual pathologies Known personal neurological pathologies And they have these criteria per group: * Group of adult subjects without ASD: Subject under guardianship or trusteeship Diagnosis of ASD Group of children without ASD : Diagnosis of ASD * Group of children with ASD ICD-10 diagnosis of PDD (Rett syndrome and Hayler syndrome) Phase 2 * Group of children without ASD : Diagnosis of ASD (confirmed or ongoing)

Locations (1)

Service de Pédopsychiatrie-CHU-TOURS

Tours, France

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