Cognitive Impairments in Psychotic Disorders

Sheba Medical Center200 enrolled

Overview

Patients with Psychotic disorders (Schizophrenia, Bipolar disorder and Schizoaffective disorder) often suffer from significant cognitive impairments, however how these develop and change over time before and after the first psychotic break is unclear. While there are data by several groups, showing that many future patients have significant cognitive impairments years before the onset of psychosis, many future patients seem to be doing well before the manifestation of psychosis, and decline steeply in functioning after their first psychotic episode. Hence the timing of the onset of cognitive impairment in patients with psychotic disorders requires further exploration. The current study will investigate the timing of cognitive impairment by using IQ tests before and after the first psychotic break

In this study the investigators aim to use the DAPAR tests (A cognitive assessment which all 17 year old Jewish adolescents in Israel undergo to participate in mandatory military service), which measures intelligence, and is equivalent to the IQ test. The subjects will be persons who had their first psychotic break, at least one year following the DAPAR tests. As part of the study, the participants will re-take the DAPAR tests, after the onset of the psychotic illness.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Psychotic Disorders Cognitive Impairment

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria - Study Group: * Patients between the ages 27-18 who had first psychotic break in the last ten years, and more than a year from the date of the DAPAR tests. * Diagnoses of schizophrenia, Bipolar disorder or Schizoaffective disorder according to DSM-5 criteria. * Previous DAPAR tests at the age of 17. Inclusion Criteria - Control group: * Participants between the ages of 27-18. * No history of psychotic break. * Previous DAPAR tests at the age of 17. Exclusion Criteria - Both groups: * Participants who did not perform the full battery of the DAPAR tests. * Participants who have been appointed a guardian. Exclusion Criteria - Control group: \- Participants who have a first-degree relative who suffers from a psychotic disorder.