The main purpose of this study is to investigate genetic, serological, immunological and microbiata diversities between different coeliac disease phenotypes and to discover applicable prognostic markers for specific phenotypes.
The recognition of clinical heterogeneity has expanded the understanding of coeliac disease, but the factors contributing to this diversity remain unclear. Moreover, since coeliac disease is highly heterogeneous, there is a need for more individualized follow-up and support and implementation of more personalized follow-up guidelines. In this study coeliac disease and dermatitis herpetiformis patients and healthy controls will be recruited. Genetic, clinical, immunological, micobiata and novel biomedical markers are compared between coeliac disease phenotypes and also controls and their prognostic value is assessed.
Study Type
OBSERVATIONAL
Enrollment
3,500
Assessment of genetic predisposition to various celiac disease phenotypes. No intervention.
Tampere University Hospital
Tampere, Finland
RECRUITINGNon-HLA variant association
phenotype specific non-HLA variants
Time frame: baseline
serum transglutaminase antibodies
Levels of serum antibodies against transglutaminase
Time frame: baseline
microbiata
skin and intestinal microbiata findings
Time frame: baseline
quality of life measure
PGWB questionnaire (22-items with values 1-6, total score range 22-132, a higher score indicating better quality of life)
Time frame: baseline
gastrointestinal symptoms
GSRS-questionnaire (15 items with values 1-7, total score 1-7 as a mean value of all scores, higher score indicating more severe symptoms)
Time frame: baseline
dietary adherence
strictness of gluten-free diet (GIP-test)
Time frame: baseline
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