Background. Consensus is lacking regarding the use of tranexamic acid (TXA) in calcaneal fracture surgery. This study aims to investigate the hypothesis that local infiltration of TXA in the post-operation would maintain hemoglobin (Hb) level, reduce incision drainage volume and risk of infection in patients with displaced intra-articular calcaneal fractures. Methods. A total of 120 patients with displaced intra-articular calcaneal fractures who received extensible lateral L-shaped approach were included in this trial and equally randomized to receive one single dose of 1g TXA or 1g normal saline after closing incision. The demographic data and fracture characteristics, intra-operative indicators, laboratory tests and Visual Analogue Scale (VAS) scores, incision drainage volume, and incision-related complications were collected and compared between the two groups.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
113
local infiltration of TXA or normal saline in the post-operation would
Hebei Medical University Third Hospital
Shijiazhuang, Hebei, China
Incision drain output (mL)
Incision drain output of post-operative day 1 and 2
Time frame: 2 days
Outcomes of laboratory test
White blood cell (10\^9/L)
Time frame: 4 days
Outcomes of laboratory test
Neutrophil count (10\^9/L)
Time frame: 4 days
Outcomes of laboratory test
Hemoglobin (g/L)
Time frame: 4 days
Incidence of surgical related complications
Complications included oozing of the blood, hematoma, or deep infection etc.
Time frame: 30 days
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