TA-65 and Aging Associated Microvascular Dysfunction

Inclusion Criteria: * Healthy Adults 18 - 35 and 65+ years of age * Subjects with clinical diagnosis of CAD Exclusion criteria will include: * 36-64 years of age without clinical diagnosis of CAD * Self-reported habitual vigorous exercise (\>20 min, 3 times per week, 1 yr) * Major Adverse Cardiovascular Event (MACE) in the last year (heart attack, stroke) * Heart Failure * Renal Impairment * \>3 Pre-existing Cardiovascular Risk Factors (healthy groups only) * Type 1 or type 2 diabetes * Uncontrolled hypertension * Current tobacco use or within last 6 months * BMI \> 35 * Hyperlipidemia * Hypercholesterolemia * Use of anti-coagulant drugs * Use of anti-platelet drugs * Erectile dysfunction medication in the past 6 months * Use of topical/non-topical steroids in last 6 months * Hormone replacement therapy (Post-Menopause or Gender Reassignment) * History of retinopathy * Documented neuromuscular disorders * Porphyria Cutanea Tarda (blistering of skin to sun; photosensitivity) * Pregnancy (young female subjects) * Allergy to lidocaine * Current diagnosis of cancer with or without active anti-cancer treatment (pharmaceuticals) or treatment within last 12 months * Active COVID-19 or within the past 3 months