Effect of Remote Ischemic Conditioning on Cerebral Hemodynamics in Patients After Intravenous Thrombolysis (RICCH-IVT)

Inclusion Criteria: 1. age ≥ 18 and \< 80 years, both sexes; 2. a clear clinical diagnosis of acute ischemic stroke and treatment with standard rt-PA (0.9 mg/kg) IVT within 4.5 h of stroke onset; 3. pre-onset modified Rankin Scale (mRS) score ≤1; 4. baseline National Institute of Health Stroke Scale (NIHSS) score ≥5 and ≤25; 5. Glasgow Coma Scale score ≥8. Exclusion Criteria: 1. having received bridging therapy (IVT plus mechanical thrombectomy); 2. previous history of atrial fibrillation or electrocardiographic evidence of atrial fibrillation; 3. contraindications to RIC treatment or previous RIC treatment or similar treatment; 4. pregnancy or breastfeeding; 5. life expectancy of ≤3 months or inability to complete the study for other reasons; 6. unwillingness to be followed up or poor treatment compliance or participation in other clinical studies; 7. had insufficient bilateral temporal bone windows for insonation of the middle cerebral artery.