Three-arm randomized clinical trial comparing two strategies of TcMS to sham stimulation in patients with VT storm. The hypothesis of the study is that TcMS will reduce the burden of VT in the 24 hours after randomization compared to sham stimulation and that TcMS with theta burst stimulation (TBS) will be more effective at reducing VT burden than low frequency TcMS.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
60
Transcutaneous Magnetic Stimulation
Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States
RECRUITINGVT Burden (24 hours)
Number of episodes of sustained ventricular tachycardia
Time frame: 24 hours after randomization
VT burden (72 hours)
Number of episodes of sustained ventricular tachycardia
Time frame: 72 hours after randomization
Freedom from VT
Freedom from sustained VT
Time frame: 24 hours after randomization
Blood Pressure
Change in mean arterial blood pressure
Time frame: Immediately before and after stimulation
Heart Rate
Change in heart rate
Time frame: Immediately before and after stimulation
Pain
Pain at site of stimulation (0-10 scale)
Time frame: Immediately after stimulation
Lead sensing
Change in implantable device lead sensing
Time frame: Immediately before and after stimulation
Lead threshold
Change in implantable device lead pacing threshold
Time frame: Immediately before and after stimulation
Lead impedance
Change in implantable device lead pacing impedance
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Time frame: Immediately before and after stimulation