Treatment of Functionally Non-significant Vulnerable Plaques in Patients With Multivessel ST-elevation Myocardial Infarction The VULNERABLE Trial

Inclusion Criteria: * Patients \> 18 years. * Successful revascularization of the culprit lesion in patients undergoing coronary angiography due to ST-segment elevation (\> 1mm in \> 2 contiguous leads, new left bundle branch block, or true posterior MI with ST depression of \>1mm in \>2 contiguous anterior leads) in the first 72 hours of the symptom's onset. * Multivessel coronary disease with non-culprit lesions located in different vessels than the culprit lesion and ranging from 40 to 69% of DS (visual estimated diameter stenosis ) by visual estimate planned for FFR-guided revascularization in staged procedure (\>24 hours and \<60 days after PCI of the culprit lesion). * Non-culprit lesions should be suitable for functional assessment with pressure wire and OCT catheter and should be suitable to be treated with a single 2.0 to 4.5 mm EES (everolimus-eluting stent ). * Subject agrees to not participate in any other clinical trial study for a period of 4 years following the inclusion in the study. * Informed consent signed. Exclusion Criteria: * Inability to provide informed consent. * Female of childbearing potential (age \<50 years and last menstruation within the last 12 months), who did not undergo tubal ligation, ovariectomy or hysterectomy. * Known intolerance to aspirin, heparin, everolimus, contrast material. * Unresolved mechanical complication or cardiogenic shock at the staged procedure. * Non-culprit study lesions located in the left main coronary artery or in coronary vessels with prior coronary revascularization (PCI or by-pass) or with distal vessel occlusion. * Patients with long, bifurcated, severely angulated or severely calcified non-culprit study lesions non suitable to be treated with a single EES implantation. * Asthma or known history of bronchial hyper-reactivity. * Chronic renal dysfunction with creatinine clearance \< 45 ml/min. * Severe comorbidities that in the opinion of the local investigators determine the patient's life expectancy \< 4 years. * Subject is currently participating in another clinical trial that has not yet completed its primary endpoint.