Predictors of Acute and Persistent Postoperative Pain in Lung Cancer Surgery

Jannie Bisgaard Stæhr100 enrolled

Overview

The aim of this observational study is to investigate if preoperative quantitative sensory testing, anxiety and depression symptoms, and biological markers are associated with the risk of developing acute and chronic postoperative pain after video-assisted Thoracoscopic surgery (VATS).

This observational study examine acute and chronic postoperative pain in patients undergoing VATS. In the study preoperative biomarkers, quantitative sensory testing and questionnaires are used to create prediction models for acute and chronic postoperative pain. The study will serve as background information on the risk factors and predictive factors as well as an exploration of the impact of surgical stress from VATS on circulation microRNA and inflammatory mediators.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Lung Cancer

Interventions

Preoperative testDIAGNOSTIC_TEST

Patients are subject to quantitative sensory testing, questionnaires, and biomarker analysis prior to surgery.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults independent of sex with an age of ≥ 18 years * Patients scheduled for VATS as a part of either examination or radical treatment of lung cancer Exclusion Criteria: * Patients who are unable to understand oral and written information. * Patients with known chronic pain in the thorax which have been persisting for at least six months before the day of surgery. * Pregnant and nursing women. * Patients receiving a planned preoperative epidural blockade during their stay. * Patients converted to open surgery.

Locations (1)

Aalborg University Hospital

Aalborg, Region of Northern Jutland, Denmark

Outcomes

Primary Outcomes

Numerical Rating Scale

Pain intensity on a Numerical Rating Scale ranging from 0 indicating no pain to 10 indicating worst pain imaginable during the first two postoperative days.

Time frame: 48 hours postoperative

Numerical Rating Scale

Pain intensity on a Numerical Rating Scale ranging from 0 indicating no pain to 10 indicating worst pain imaginable at follow up. Collected using the Brief Pain Index

Time frame: 365 days postoperative

Secondary Outcomes

Total equipotent opioid dose

48 hours postoperative

Time frame: Total equipotent opioid dose in milligrams during the first 48 hours after surgery.

Time to first administration of opioid

48 hours postoperative

Time frame: Time in hours to first postoperative administration of Pro Re Nata (PRN) opioids

Mobilisation

Time in hours to full mobilisation defined as walking with or without aids.

Time frame: 48 hours postoperative

Patient-reported satisfaction of postoperative pain management assessed by self-made questionnaire in Danish

Patients are asked to fill out a questionnaire rating their general satisfaction with pain management and sufficiency of pain treatment on a scale from 0 to 10. The questionnaire also assess whether the patients had any perceived side effects and how uncomfortable they were on a scale from 0 to 10.

Time frame: Measured twice. Once 48 hours after surgery or at non fixed time(on average 4 days and a maximum of 3 months) as well as at 365 days

Data from ClinicalTrials.gov

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