Phase I Clinical Trial of a Candidate PCV13 in Healthy People

Inclusion Criteria: * Satisfy the age requirements of the clinical trial; willing to provide proof of identity; * Subjects or guardians must provide informed consent forms with personal signature and date; * Male and female of childbearing age should agree to take effective contraception measures; * Subjects or guardians can obey the requirements of the clinical study; * Axillary temperature below 37.3 °C. Exclusion Criteria: * Laboratory indicators (expect those have no clinical significance) out of normal ranges required; * Received any pneumococcal vaccine; * Allergic history to any drugs, vaccine or vaccine-related component; * Infants with congenital malformations, developmental disorders, genetic defects, or severe malnutrition; * Infants diagnosed with pathological jaundice that lasts for 2\~4 weeks and occurs repeatedly; * Breast-feeding or pregnant women, or positive U-HCG; * High blood pressure uncontrolled by medication; * Known or suspected immune deficiency or immune suppression; * Serious congenital malformation, history of organ resection or serious chronic illness; * Received blood products or intravenous immunoglobulin (except Hepatitis B immunoglobulin); * History of clinic-proven or serology-proven infectious disease especially caused by streptococcus pneumoniae; * History of convulsions, epilepsy or encephalopathy or a family history of mental illness; * A vaccination-related contraindications that other investigator believes; * Plans to participate in or is participating in any other clinical study; * Any other factors judged by investigator that may interfere subject's compliance with the protocol.