This study is aimed to investigate if Lemon Balm Extract supplementation is beneficial for the relief of stress, depression and anxiety in healthy adults.
Lemon balm (Botanical name: Melissa officinalis L.) is a herbal plant belongs to the Lamiaceae (mint) family, and currently of wide scientific interest as possible adjuvant for calming effect. Lemon balm is one of the most popular and widely used medicinal herbs in central and southern Europe, the Mediterranean region, and west Asia. The European Scientific Cooperative on Phytotherapy (ESCOP) recommends the use of lemon balm to relieve of mild symptoms of anxiety, including mental stress, restlessness, and irritability. Historically, Lemon balm has been widely used in Asian traditional medicine as a sedative to treat many psychiatric disorders, such as stress, depression, anxiety, and insomnia. Lemon balm has shown anti-depressant, anxiolytic, and anti-insomnia effects both in human clinical trials and in animal model studies.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
102
Oral 200 mg Lemon Balm supplement tablet Twice a day for three-weeks
Matched placebo tablet Twice a day for three-weeks
Ayub Teaching Hospital
Abbottābād, Pakistan
Changes in the level of depression
Improvement in the Depression score in the Depression Anxiety and Stress Scale (DASS)
Time frame: 3 weeks
Changes in the level of anxiety
Improvement in the Anxiety score in the Depression Anxiety and Stress Scale (DASS)
Time frame: 3 weeks
Changes in the level of stress
Improvement in the Stress score in the Depression Anxiety and Stress Scale (DASS)
Time frame: 3 weeks
Changes in sleep quality
Improvement in the Pittsburgh Sleep Quality Index (PSQI) scale score
Time frame: 3 weeks
Changes in mental wellbeing
Improvement in the Warwick Edinburgh Mental Wellbeing Scale (WEMWBS) score
Time frame: 3 weeks
Changes in Positive and Negative Emotional Feelings
Improvement in the Positive and Negative Affect Scale (PANAS) score
Time frame: 3 weeks
Changes in the Quality of Life (QoL)
Improvement in the WHO QOL-BREF scale scores
Time frame: 3 weeks
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