A Study of Baked Milk Tolerance to Treat Eosinophilic Esophagtis

Mayo Clinic7 enrolled

Overview

This research is being done to see if patients with milk-triggered EoE are able to tolerate baked milk in their diet and if there is a threshold amount of straight milk that is tolerable.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Eosinophilic Esophagitis

Interventions

Baked MilkDIETARY_SUPPLEMENT

Participants to regularly eat a baked milk muffin for 6 weeks

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosed with Eosinophilic esophagitis ≥ 15 eosinophils per HPF * Going through or completed the six-food elimination diet, with milk only or milk plus one additional food identified as a trigger Exclusion Criteria: * Patients with conditions known to be associated with esophageal eosinophilia, including Crohn's disease, Churg-Strauss, achalasia, and hypereosinophilic syndrome * Topical swallowed steroids within 8 weeks of study enrollment * Inability to read due to: Blindness, cognitive dysfunction, or English language illiteracy

Locations (1)

Mayo Clinic Minnesota

Rochester, Minnesota, United States

Outcomes

Primary Outcomes

Histological remission

Number of patients in histologic remission at the end of a 6 week trial of baked milk. Histologic remission is defined by \<15 eos per HPF on cytosponge.

Time frame: 6 weeks

Secondary Outcomes

Symptomatic remission

Number of patients in symptomatic remission after a 6 week trial of baked milk. Symptomatic remission is defined by EEsAI PRO score of \<20

Time frame: 6 weeks

Data from ClinicalTrials.gov

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