Mast Cells Are Involved in the Mechanism of NPSLE Epilepsy

Inclusion Criteria: 1. Healthy control group * Voluntary signing of informed consent; * Healthy volunteers older than 18 years old and less than 50 years old, regardless of gender; * No systemic diseases or neurological symptoms or signs; * According to the judge's judgment, healthy volunteers matching the NPSLE epilepsy group in terms of gender, age, and education level were selected as the control group. 2. SLE group * Voluntary signing of informed consent; * Age greater than 18 years old, less than 50 years old, gender is not limited; * Patients with SLE who meet diagnostic criteria. 3. NPSLE Epilepsy Group * Voluntary signing of informed consent; * Age greater than 18 years old, less than 50 years old, gender is not limited; * Patients with NPSLE epilepsy who meet diagnostic criteria. Exclusion Criteria: 1. SLE group * patients with SLE with other autoimmune diseases; * Previous seizures, psychiatric abnormalities and other manifestations; * MR of the head has obvious abnormal signals in the skull or EEG shows abnormal signals; * History of use of hormones and immunosuppressants; * The investigators judged that it was not suitable to participate in this study. 2. NPSLE Epilepsy Group * prior history of epilepsy or clear cranial MR findings suggesting structural abnormalities; * Presence of precipitating seizures such as sleep deprivation, high fever, infection, long-term abstinence from alcoholism * Interrupt, patients with systemic diseases such as hypoglycemia, severe electrolyte disorders, malignant lesions, progressive or degenerative diseases, severe liver and kidney insufficiency and other metabolic diseases; * The investigators judged that it was not suitable to participate in this study.