This is a multi-center, multidisciplinary, open-label, randomized controlled prospective clinical study.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
100
once daily 0.01% hypochlorous acid topical treatment via ultrasonic atomization for 2 weeks
once daily eyelid wipes for 2 weeks
Eye & ENT Hospital of Fudan University
Shanghai, Shanghai Municipality, China
RECRUITINGOSDI
0-100 score based on the ocular surface disease index (OSDI) questionnaire
Time frame: Change from baseline OSDI at 2 weeks
meibum quality
Meibum quality were measured by using firm digital pressure applied over 5 lower lid glands. Meibum quality was graded as: grade 0, clear; grade 1, cloudy; grade 2, cloudy with granular debris; and grade 3, thick like toothpaste.
Time frame: Change from baseline meibum quality score at 2 weeks
Corneal fluorescein staining
scored by Oxford staining score
Time frame: Change from baseline corneal fluorescein staining at 2 weeks
FBUT
fluorescent tear break up time fluorescein tear film break-up time
Time frame: Change from baseline FTBUT at 2 weeks
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