Safety and Efficacy of Remote Ischemic Conditioning for Spontaneous Intracerebral Hemorrhage

Inclusion Criteria: 1. Age ≥18 years. 2. Supratentorial intracerebral hemorrhage confirmed by brain CT scan. 3. No disability in the community before ICH (premorbid mRS≤ 1). 4. NIHSS score ≥ 6 and GCS ≥ 8 upon presentation. 5. Able to commence RIC treatment within 24 hours of stroke onset. 6. Systolic blood pressure ≤ 180 mmHg before randomization. 7. Signed and dated informed consent is obtained. Exclusion Criteria: 1. Definite evidence of secondary ICH, such as structural abnormality, brain aneurysm, brain tumor, thrombolytic drug. 2. Hematoma with a mid-line shift, cerebral herniation or isolate intraventricular hemorrhage. 3. Already booked for surgical treatment. 4. Life expectancy of less than 180 days due to comorbid conditions. 5. Concurrent use of anticoagulation drugs including Warfarin, dabigatran, rivaroxaban or coagulopathy (defined as INR, APTT, and PT beyond the upper limit of normal range). 6. Any soft tissue, orthopedic, or vascular injury, wounds or fractures in healthy upper limb which may pose a contraindication for application of RIC. 7. Severe hepatic and renal dysfunction, or ALT/AST \>3 times upper limit of normal, or serum creatinine \>265umol/l. 8. Known pregnancy or breastfeeding. 9. Patients being enrolled or having been enrolled in other clinical trial within 3 months prior to this clinical trial. 10. A high likelihood that the patient will not adhere to the study treatment and follow up regimen. 11. Patients unsuitable for enrollment in the clinical trial according to investigators decision making.