Endothelial Glycocalyx Damage in Brain Death Organ Donors

N/AActive Not RecruitingNCT05609123

University Hospital Hradec Kralove100 enrolled

Overview

The study aims the assessment of endothelial glycocalyx (EG) degradation in deceased organ donors. There is a lack of organs for the transplantation program. By the description of the EG status, we can open room for organ optimization before transplantation and improve the organ function after transplantation in marginal donors.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Brain Damage Due to Hypoxia Organ Donors Organ Transplant Failure or Rejection

Interventions

Endothelial glycocalyx damage assessmentDIAGNOSTIC_TEST

Degradation products of endothelial glycocalyx will be assessed in the blood and urine.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients in critical condition declared as brain dead by clinical examination Exclusion Criteria: * N/A

Locations (1)

University Hospital Hradec Kralove

Hradec Králové, Czechia

Outcomes

Primary Outcomes

Markers of endothelial glycocalyx damage

Levels of syndecan-1 in serum and urine

Time frame: baseline at the time of inclusion

Data from ClinicalTrials.gov

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