The goal of this clinical trial is to compare the rhythm control effect in hypertrophic non-obstructive patients with non-paroxysmal atrial fibrillation by either concomitant catheter endocardial and thoracoscopic epicardial ablation or catheter ablation alone. The study aims to see if concomitant hybrid ablation can more effectively achieve rhythm control effect than catheter ablation alone in non-paroxysmal atrial fibrillation patients with hypertrophic cardiomyopathy.
After informed consent, 66 eligible admissions will be recruited in 2 centers. Eligible participants will be randomly divided (1:1) into either hybrid or catheter ablation arms, looking for a primary outcome of 1-year freedom from atrial arrhythmias.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
66
simultaneous thoracoscopic epicardial and catheter endocardial ablation
catheter endocardial ablation
Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College
Beijing, China
RECRUITINGFreedom from documented recurrence (off-AADs)
freedom from documented AF/AT episodes \>30 seconds (off-AADs) by 72-hour holter monitoring
Time frame: within 3-12 months
All cause mortality
death by any reason
Time frame: within 12 months
Cardiovascular related mortality
death that related to cardiogenic causes
Time frame: within 12 months
Cerebral infarction/ischemia
Any stroke or TIA diagnosed in the clinical record after the completion of the intervention
Time frame: within 12 months
Periferal arterial embolism
Periferal arterial embolism
Time frame: within 12 months
All-cause rehospitalization
Rehospitalized by any reason
Time frame: within 3-12 months
Heart failure related rehospitalization
Rehospitalized by the cause of heart failure episode
Time frame: within 3-12 months
Freedom from documented recurrence (on-AADs)
freedom from documented AF/AT episodes \>30 seconds (on-AADs) by 72-hour holter monitoring
Time frame: within 3-12 months
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