Impact of Time Restricted Feeding on Daily Protein Requirements

University of Arkansas61 enrolled

Overview

The investigators aim to assess 24-hour protein kinetics at two different levels of protein intake: 0.8 (RDA) and 1.6g/kg/day (2RDA) during a normal dietary (TRAD) and a time restricted feeding (TRF) pattern in older adults. Individuals in the TRF pattern will only consume food during a 6-hour eating period and fast for the remaining 18 hours. Individuals in the TRAD pattern will consume isocaloric and isonitrogenous (RDA or 2RDA) diet but consume an all-beef-breakfast. Participants will consume oral stable isotopes to measure muscle protein synthesis (MPS), whole-body muscle protein breakdown (MPB), and whole-body protein balance (WBPB). Appropriate muscle, blood samples, and urine will be collected throughout a 24-hour metabolic trial following a 2-day controlled diet.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Enrollment

Conditions

Nutrition Disorders in Old Age

Interventions

isocaloric, isonitrogenous mealsOTHER

Participants will eat prepared study meals for 3 days that have either the RDA of protein per day or twice the RDA of protein per day.

Eligibility

Sex: ALLMin age: 50 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Men and women ages 50-75 years. 2. BMI 20-30 kg/m2 inclusive. 3. Capable of providing informed consent. 4. COVID-19 negative and/or asymptomatic Exclusion Criteria: 1. Subject who does not/will not eat animal protein sources. 2. Body mass index \<20 or \>30. 3. Hemoglobin \<10g/dL at screening. 4. Platelets \<150,000/uL at screening. 5. History of diabetes. 6. History of chemotherapy or radiation therapy for cancer in the 6 months prior to enrollment. 7. History of gastrointestinal bypass/reduction surgery. 8. History of a chronic inflammatory disease (e.g. what?) 9. Currently receiving androgen (e.g., testosterone) or anabolic (e.g., GH, IGF-I) therapy. 10. Currently using prescription blood thinning medications. 11. Currently using corticosteroid medications. 12. Unable or unwilling to suspend aspirin use for 7 days prior to Visit 3. 13. Unwilling to avoid using protein or amino-acid supplements during participation. 14. Subjects who are unwilling to fast overnight. 15. Participating in \>200 minutes/week of vigorous exercise and/or \>4 days/week of resistance training.

Locations (1)

University of Arkansas for Medical Sciences

Little Rock, Arkansas, United States

Outcomes

Primary Outcomes

Whole-body protein balance

Volume of net protein produced per unit of time

Time frame: 24 hours

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.