Acute Responses to Arm-Crank Exercise on Cardiovascular Function of Patients With Peripheral Artery Disease

University of Nove de Julho17 enrolled

Overview

The aim of this study is to analyze acute responses of arm-cranking exercise on cardiovascular function of peripheral arterial disease patients and compare it to the main exercise recommendation, walking exercise.

Twenty patients with peripheral arterial disease and claudication symptoms will be recruited. The patients will perform three experimental conditions, in randomized order (walking, arm-cranking and control). The exercise conditions will be composed of 15 bouts of 2 minutes exercise with an intensity equivalent to 13-15 on Borg's Subjective Perceived Exertion Scale. During the experimental conditions (walking, arm-cranking and control) blood pressure, heart rate and cerebral blood velocity will be evaluated, along with perceived exertion and affective responses. Before and after experimental conditions, vascular function, blood pressure, heart rate variability, cerebral blood velocity, subjective perceived exertion and affective responses will be evaluated.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Intermittent Claudication Cardiovascular Diseases Blood Pressure Endothelial Dysfunction Peripheral Arterial Disease

Interventions

ExerciseBEHAVIORAL

Three conditions will be tested: Walking, arm-cranking and control condition.

Eligibility

Sex: ALLMin age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Peripheral arterial disease diagnosis; * Age ≥ 40 years old; * If a woman, be in menopause without the use of hormone replacement therapy; * Do not be an active smoker; * Be apt to perform exercise. Exclusion Criteria: * Any change in medication; * Any health impairment that contraindicates the practice of physical exercise.

Locations (1)

Nove de Julho University

São Paulo, Brazil

Outcomes

Primary Outcomes

Change from baseline in vascular function post-exercise in the brachial and femoral arteries.

Vascular function will be measured in the supine position by the flow-mediated dilation (FMD) technique, through Doppler ultrasonography.

Time frame: Change from baseline at post-intervention, after 20 minutes.

Secondary Outcomes

Change from baseline in blood pressure post-exercise.

Blood pressure will be measured by an automatic monitor.

Time frame: Change from baseline at post-intervention, after 10 minutes.

Change from baseline in heart rate variability post-exercise.

Autonomic modulation of the cardiovascular system will be measured by the heart rate variability (HRV) technique, by a heart rate monitor valid for this function.

Time frame: Change from baseline at post-intervention, after 30 minutes.

Change from baseline in cerebral blood velocity post-exercise.

Cerebral blood velocity will be measured by a transcranial doppler ultrasound.

Time frame: Change from baseline at 35 minutes after the beginning of the exercise.

Data from ClinicalTrials.gov

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