This is an interventional pilot study to determine whether implementation of a supervised exercise program can improve outcomes in subjects undergoing allogeneic HCT. The primary objective is to determine feasibility. Up to 60-72 evaluable subjects will be enrolled. Evaluable subjects are defined as those participating in the exercise intervention.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
72
Pre-frail and frail potential HCT recipients 60 years and older will participate in a supervised exercise program from the time of enrollment up until HCT admission. Exercise compliance will be measured in part through physical activity trackers.from time of discharge from HCT until day +100 post-HCT. All HCT recipients 60 years and older will participate in a supervised exercise program from the time of discharge from HCT admission until day +100 post-HCT. Exercise compliance will be measured in part through physical activity trackers.
All HCT recipients 60 years and older will participate in a supervised exercise program from the time of discharge from HCT admission until day +100 post-HCT. Exercise compliance will be measured in part through physical activity trackers.
Penn Medicine
Philadelphia, Pennsylvania, United States
RECRUITINGProportion of enrolled subjects who participate in the supervised exercise program
Time frame: From 3 months prior to HCT to 100 days after HCT
Median number of exercise sessions delivered pre-HCT and post-HCT.
Time frame: From 3 months prior to HCT to 100 days after HCT
Hospital LOS for HCT
Time frame: From date of randomization until the date of first documented discharge from the hospital, assessed up to 100 months
Rate of readmission
Time frame: From time of discharge from initial hospital stay up through 1-2 years after HCT
6-month and 1-year overall mortality
Time frame: From day 0 of HCT to 6 months and 1-year] 6. 1-year and 2-year OS
1-year and 2-year OS
Time frame: From day 0 of HCT to 1-year and 2-years
1-year and 2-year PFS
Time frame: From day 0 of HCT to 1-year and 2-years
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