A New Marker for Early Diagnosis of Pneumoperitoneum-Related Acute Kidney Injury: Insulin-Like Growth Factor-1 (IGF-1)

Baskent University25 enrolled

Overview

In our study, to show the effect of pneumoperitoneum on acute kidney injury in patients scheduled for laparoscopic surgery, NGAL and IGF-1 values will be measured before, after and 24 hours after pneumoperitoneum, and these values will be compared. In our study, we aimed to investigate the effect of pneumoperitoneum applied on acute kidney injury in patients who underwent laparoscopic surgery. Creatinine and NGAL have been used successfully in the follow-up of acute kidney injury. Our study investigates whether IGF-1 will be an effective indicator in acute kidney injury by comparing IGF-1 and NGAL values before pneumoperitoneum, after pneumoperitoneum and at the postoperative 24th hour.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Acute Kidney Injury (Nontraumatic)Pneumoperitoneum

Interventions

We need to diagnose acute kidney injury in the early postoperative period. The markers examined so far do not provide enough information to diagnose acute kidney injury early. For this reason, many different biomarkers are used in the early diagnosis of acute kidney injury in many parts of the world. Thanks to our research, we can recognise the development of acute kidney injury at an early stage and determine whether a previously unused biomarker (IGF-1) is effective in the early diagnosis of acute kidney injury.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients aged 18-70 years of both sexes * ASA I-III Patients Exclusion Criteria: * Obesity, * Chronic Kidney Disease, * Chronic Renal Failure, * Acute Renal Failure, * Peripheral and ischemic vascular disease, * Chronic Heart Failure, * History of anaphylaxis, * A-V block, * Creatinine level \>1.4, * Neuromuscular disease, * Malignant hypertension, * Pyelonephritis, * Urinary tract infectio, * Severe inflammation/possible sepsis, * Active malignancy, * Patients with surgery reversion to laparotomy, * Hemodynamic instability, need for vasopressors, * Severe bleeding requiring blood transfusion,

Outcomes

Primary Outcomes

Diagnosis of acute kidney injury in the early postoperative period with IGF-1 (insulin like growth factor-1)

The researchers investigate whether IGF-1 will be an effective indicator in acute kidney injury by comparing IGF-1 and NGAL (Neutrophil gelatinase-associated lipocalin) values before pneumoperitoneum, after pneumoperitoneum and at the postoperative 24th hour.

Time frame: before pneumoperitoneum, after pneumoperitoneum, and at the postoperative 24th hour.