Effect of Very Early and Rapid Lowering Cholesterol With Evolocumab on Left Ventricular Remodeling in Patients With Anterior STEMI Undergoing Primary PCI

Inclusion Criteria: * Age 18-75 years * Persistent chest pain or chest discomfort * Onset within 12 hours * ST-segment elevation ≥0.1 millivolt in two adjacent precordial leads, or a new-onset left bundle branch block with dynamic changes * Primary PCI is planned Exclusion Criteria: * Contraindications to Statins or PCSK9 inhibitors * Prior intravenous thrombolytic therapy * Prior use of Statins, PCSK9 inhibitors or Ezetimibe * Cardiogenic shock * Acute heart failure or pulmonary edema * Prior chronic heart failure * Severe hepatic and renal insufficiency (alanine aminotransferase ≥5 upper limit of normal; estimated glomerular filtration rate \<30ml/min/1.73m2, or on dialysis) * Prolonged (\> 20 minutes) cardiopulmonary resuscitation * Definite mechanical complications (including ventricular septal perforation, or rupture of the Papillary tendon bundle, or rupture of the left ventricular free wall) * Malignant arrhythmias that are difficult to control with drugs * Severe chronic obstructive pulmonary disease or respiratory failure * Severe infection * Neurological disorders * Bleeding history of cerebrovascular, gastrointestinal, respiratory, urinary or other organs within the last month * Active bleeding or bleeding diatheses * Use of anticoagulants * Malignant tumors or other pathophysiological conditions with an expected survival time of less than 1 year * Pregnant or lactating women