Effect of High-Definition Transcranial Direct Current Stimulation (HD-tDCS) on Attentional Control: an fMRI Study on Healthy Participants

University of Tehran24 enrolled

Overview

In a randomized, triple-blind, sham-controlled clinical trial, we will assess the effect of a single session frontal cortex High-Definition transcranial Direct Current Stimulation (HD-tDCS) on brain activity and functional connectivity underlying the behavioral change in attentional control in healthy participants. Participants will be recruited after meeting the inclusion criteria and will be randomly assigned to active or sham stimulation groups. All participants will undergo resting-state functional Magnetic Resonance Imaging (rsfMRI) scan and perform an Attention Network Test (ANT) in a functional Magnetic Resonance Imaging (fMRI) scanner before and after receiving a single session of active or sham HD-tDCS.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Healthy Volunteers

Interventions

Eligibility

Sex: ALLMin age: 20 YearsMax age: 39 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Right-handed healthy adults * Age range 20-39 years * Normal or corrected-to-normal vision * Willing and capable of following study protocol requirements given in the informed consent Exclusion Criteria: * Psychiatric conditions (e.g., depression and generalized anxiety disorder, etc.) * Medical illness or neurological disorder (e.g., cardiovascular illness, anemia, respiratory illness, neurological illness, seizure, etc.) * Current abuse of drugs or alcohol * Any conditions that prevent undergoing an fMRI scan or tDCS stimulation according to the fMRI and tDCS safety checklists

Outcomes

Primary Outcomes

Change in Attention Network Test (ANT) performance before and after the intervention (active versus sham HD-tDCS)

Time frame: Immediate before and immediate after intervention

Change in resting state functional connectivity before and after the intervention (active versus sham HD-tDCS)

Time frame: Immediate before and immediate after intervention

Change in task-based functional connectivity during Attention Network Test (ANT) before and after the intervention (active versus sham HD-tDCS)

Time frame: Immediate before and immediate after intervention

Change in the blood-oxygen-level-dependent (BOLD) signal during Attention Network Test (ANT) before and after the intervention (active versus sham HD-tDCS)

Time frame: Immediate before and immediate after intervention

Secondary Outcomes

Side effect checklist for transcranial Direct Current Stimulation (Reported as Yes or No)

Time frame: One day after simulation session

Effect of High-Definition Transcranial Direct Current Stimulation (HD-tDCS) on Attentional Control: an fMRI Study on Healthy Participants

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts