This study aims to examine patient tolerability of personalized dietary fibre consumption recommendations (high-pectin diet versus high-B-fructan diet based on personalized responses), provided by an IBD dietician, based on our novel translational research findings.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
600
UC and healthy control participants randomized to receive recommendations provided by a dietician increasing consumption of foods high in pectin
UC and healthy control participants randomized to receive recommendations provided by a dietician increasing consumption of foods high in B-fructan
UC and healthy control participants to receive recommendations provided by a dietician increasing consumption of foods high in pectin based on personal host (biopsy) and microbe (stool) response at baseline
University of Alberta Hospital
Edmonton, Alberta, Canada
RECRUITINGHealth Sciences Centre Hospital
Winnipeg, Manitoba, Canada
RECRUITINGDiet tolerability
Percentage of patients able to tolerate a personalized fiber diet provided by a dietitian will be evaluated at week 4 by measure of patient symptom score (PROMIS questionnaire) and willingness to continue adherence to diet advice provided.
Time frame: 4 weeks
Inflammatory response to diet
Host inflammatory response to personalized dietary fibre recommendations provided by dietitian will be determined by examining changes in markers of inflammation in blood and stool
Time frame: 1 week, 4 weeks, 8 weeks, 12 weeks
Microbiota changes in response to diet
Host microbiota response to personalized dietary fibre recommendations provided by dietitian will be determined by examining changes in microbe abundance, diversity and functions by shotgun metagenomics in stool
Time frame: 1 week, 4 weeks, 8 weeks, 12 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
UC and healthy control participants to receive recommendations provided by a dietician increasing consumption of foods high in B-fructan based on personal host (biopsy) and microbe (stool) response at baseline