Effect of New Oral Treatment for Hepatitis C Virus on Seminal Parameters

Benha University200 enrolled

Overview

Hepatitis C virus is commona viral infection. Direct-acting antiviral (DAA) oral drugs has been used in treatment of HCVs. the effect of these drugs on male infertility is still under investigation.

Semen analysis will be done to male patients with HCV before and after treatment with DAA. The included men will take therapy for 3 months and HCV RNA titter will be evaluated. changes of seminal parameters will be recorded and analyzed.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

200

Conditions

Male Infertility HCV

Interventions

Sofosbuvir +daclatasvir+ simeprevir+RibavirinDRUG

Oral daily dose of Sofosbuvir +daclatasvir + simeprevir+ Ribavirin for 3 months

Eligibility

Sex: MALEMin age: 18 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: Men patients with HCV Exclusion Criteria: Patients with other hepatic disease, endocrinal disorder, malignancy, or urinary tract infection.

Locations (2)

Faculty of Medicine, Benha University

Al Qalyūbīyah, Benha, Egypt

Benha Faculty of Medecine

Banhā, Egypt

Outcomes

Primary Outcomes

Treatment of HCV

HCV titer by PCR is below detection level

Time frame: 3 months

Data from ClinicalTrials.gov

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