Synovitis in Patients With Osteoarthritis

The Affiliated Hospital of Qingdao University272 enrolled

Overview

To study synovial membrane (SM) inflammation in suprapatellar fossa in advanced knee osteoarthritis (OA), and to correlate the pathological features with clinical findings.

Study Type

OBSERVATIONAL

Enrollment

272

Conditions

Osteoarthritis, Knee

Interventions

Total knee arthroplasty due to advanced osteoarthritis.PROCEDURE

Postoperative usage of intravenous methylprednisolone

Eligibility

Sex: ALLMin age: 55 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients undergoing elective, unilateral, primary TKA for advanced osteoarthritis. Exclusion Criteria: \- revisions, bilateral procedures, alcohol or medical abuse, administration of any glucocorticoids during the 3 months prior to surgery, and/or a history of serious cardiac or cerebrovascular problems, severe liver or kidney failure, and/or connective tissue disease including rheumatoid arthritis, ankylosing spondylitis, and systemic lupus erythematosus.

Locations (1)

The affiliated hospital of Qingdao University

Qingdao, Shandong, China

Outcomes

Primary Outcomes

Correlation between pathological features and clinical scores

Time frame: 1 day.

Correlation between pathological features and laboratory index

Time frame: 1 day

Data from ClinicalTrials.gov

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