Effect of Body Position on Hemodynamics in Patients With Acute Ischemic Stroke Undergoing Ultra-early Reperfusion Therapy

Yi Yang100 enrolled

Overview

The aim of this study was to determine the differences in hemodynamics between different positions in patients undergoing ultra-early reperfusion therapy.

Hemodynamic stability can prevent hypoperfusion or hyperperfusion after reperfusion therapy. It has been reported in a large number of literatures that body position has an effect on hemodynamics, but the effect of different body positions on the hemodynamics of patients undergoing ultra-early reperfusion therapy is not clear. In this study, we hypothesized that the hemodynamics of patients undergoing ultra-early reperfusion therapy would differ between different positions.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

100

Conditions

Acute Ischemic Stroke

Interventions

Transcranial Doppler.DEVICE

Spontaneous arterial blood pressure will be simultaneously recorded using a servo-controlled plethysmograph on the left or right middle finger with an appropriate finger cuff size. Continuous cerebral blood flow velocities of bilateral middle cerebral artery will be assessed noninvasively using transcranial Doppler.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age≥18 years, \< 80 years, regardless of sex； * Patients with clinically confirmed acute ischemic stroke who received intravenous thrombolysis or emergency endovascular treatment; * Baseline National Institute of Health stroke scale（NIHSS）score ≤25; * Baseline Glasgow Coma Scale (GCS) ≥8; * Signed and dated informed consent is obtained Exclusion Criteria: * The patient has clear indications or contraindications, such as active vomiting, spinal cord injury； * Clinicians considered that the assigned body position could not be maintained; Patients unable to cooperate with all noninvasive beat-by-beat continuous BP monitoring; * Poor temporal window penetration; * Patients with diseases that seriously affect hemodynamics, such as atrial fibrillation, anemia, and hyperthyroidism; * Previous history of atrial fibrillation or ECG showing atrial fibrillation or arrhythmia; * Pregnant or lactating women; * Poor treatment compliance; * Complicated with severe systemic diseases, such as heart failure, respiratory failure, renal failure, gastrointestinal bleeding, coagulopathy, malignant tumors.

Locations (1)

The First Hospital of Jilin University

Changchun, Jilin, China

Outcomes

Primary Outcomes

Differences in blood pressure variability（BPV）between different positions

BPV is defined as blood pressure oscillations in relation to the mean values.

Time frame: 0-7 days

Differences in heart rate variability (HRV) between different positions

HRV is defined as heart rate oscillations in relation to the mean values.

Time frame: 0-7 days

Secondary Outcomes

The difference of middle cerebral artery blood flow velocity between different positions.

Continuous cerebral blood flow velocities of bilateral middle cerebral artery will be assessed noninvasively using transcranial Doppler.

Time frame: 0-7 days

Data from ClinicalTrials.gov

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