CBD, Nutrient Metabolism and Energy Intake

Loughborough University15 enrolled

Overview

CBD may affect metabolic control and energy intake. However, there is currently little data regarding these specific outcomes in humans. Therefore, this study will investigate whether a single 300 mg dose of CBD can improve metabolic control following a meal and/or reduce energy intake at a subsequent meal. Healthy, adult volunteers will complete two conditions in a crossover design, comparing outcomes following both CBD and placebo supplementation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Glucose Metabolism Disorders (Including Diabetes Mellitus)Lipid Metabolism Disorders Appetitive Behavior

Interventions

Acute oral CBD supplementationDIETARY_SUPPLEMENT

1 ml hemp oil containing 300 mg CBD, within gelatin capsules, ingested orally.

Acute oral placebo supplementationDIETARY_SUPPLEMENT

1 ml hemp oil containing no CBD, within gelatin capsules, ingested orally.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: • Self-report as healthy, male or female, aged 18-50, body mass index ≥18.5 and \<30.0 Exclusion Criteria: * Currently engage in \>10 hours moderate or vigorous intensity physical activity per week * Have consumed CBD or cannabis at all within the past two months * Have used CBD or cannabis regularly (\>2x in a week) within the past four months * Are suffering from any clinically significant illness * Have regularly used tobacco within the previous 6 months (\> 2/week) * Currently use any prescription or over-the-counter medications (except for hormonal contraception and simple painkillers) * Have given a standard blood donation within 30 days of screening * Are currently pregnant or lactating * Are allergic/intolerant to any ingredients in food items provided during the study

Locations (1)

Loughborough University

Loughborough, Leicestershire, United Kingdom

Outcomes

Primary Outcomes

Energy intake

Self-selected energy intake at an ad libitum mixed meal

Time frame: ~5-30 minutes (time taken to eat a single meal)

Postprandial Glycaemia

Plasma glucose response to a mixed meal (plasma glucose concentrations and area under curve)

Time frame: 3 hours

Postprandial Triglyceridaemia

Plasma triglyceride response to a mixed meal (plasma triglyceride concentrations and area under curve)

Time frame: 3 hours

Secondary Outcomes

Postprandial Insulinaemia

Plasma Insulin response to a mixed meal (plasma insulin concentrations and area under curve)

Time frame: 3 hours

Data from ClinicalTrials.gov

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