Intubating Conditions of Neuromuscular Blockade

N/ACompletedNCT05620108

Mayo Clinic170 enrolled

Overview

The purpose of this research is to learn about the difference in the endotracheal intubation condition (ease of using a device to view vocal cords, position of vocal cords, and patient's reaction to endotracheal tube insertion) and determining the appropriate time to perform the intubation.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

170

Conditions

Endotracheal Intubation

Interventions

Endotracheal Intubation at TOFC=1PROCEDURE

Intubation using a video laryngoscopy will be performed after train-of-four (TOFC) stimulation indicates neuromuscular blockade

Endotracheal Intubation 2 minutes after rocuronium administrationPROCEDURE

Intubation using a video laryngoscopy will be performed 2 minutes after administration of rocuronium at 0.6 mg/kg (usual current clinical routine)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients willing to participate and provide an informed consent. * Patients undergoing elective surgical procedures that require use of NMBA agents (rocuronium) administered intraoperatively. Exclusion Criteria: * Patients with disorders, such as stroke, carpal tunnel syndrome, broken wrist with nerve damage, Dupuytren contracture, or any similar wrist injury. * Patients with systemic neuromuscular diseases such as myasthenia gravis. * Patients with significant organ dysfunction that can significantly affect pharmacokinetics of neuromuscular blocking and reversal agents; i.e., severe renal impairment or end-stage liver disease. * Patients having surgery that would involve prepping the arm into the sterile field. * Patients receiving a rapid sequence induction.

Locations (1)

Mayo Clinic Florida

Jacksonville, Florida, United States

Outcomes

Primary Outcomes

Number of Subjects With Optimal Intubating Conditions

The number of subjects who had optimal intubating conditions (total composite score of 3) will be evaluated by the healthcare providers using a scale that includes 3 variables (ease of laryngoscopy, vocal cord position, and reaction to tracheal tube insertion) with 3 response options per each evaluation. The composite score (1-3) will be used, with the lowest total score of 3 correlating with optimal intubating conditions and the highest score of 9 representing the worse possible intubating conditions.

Time frame: Approximately 15 minutes after intubation

Data from ClinicalTrials.gov

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