Transcranial Alternating Current Stimulation (tACS) in Patients With Ataxia

Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia26 enrolled

Overview

The aim of the study is to evaluate the effects on motor and cognitive performance of transcranial alternating current stimulation (tACS) compared to transcranial direct current stimulation (tDCS) and placebo stimulation (sham) in patients with neurodegenerative ataxia to identify a possible rehabilitation protocol.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Ataxia Spinocerebellar Ataxias Multiple System Atrophy Ataxia With Oculomotor Apraxia CANVAS

Transcranial stimulation over the cerebellar hemispheresDEVICE

Single session of Transcranial stimulation over the cerebellar hemispheres

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with a cerebellar syndrome and quantifiable cerebellar atrophy Exclusion Criteria: * Severe head trauma in the past * History of seizures * History of ischemic stroke or hemorrhage * Pacemaker * Metal implants in the head/neck region * Severe comorbidity * Intake of illegal drugs * Pregnancy

Locations (1)

ASST Spedali Civili di Brescia

Brescia, BS, Italy

Outcomes

Primary Outcomes

Change in the International Cooperative Ataxia Rating Scale (ICARS) Score From Baseline

International Cooperative Ataxia Rating Scale (ICARS): semi-quantitative 100-point scale, yielding a total score of 0 (no ataxia) to 100 (most severe ataxia).